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Chidamide inhibits the NOTCH1-MYC signaling axis in T-cell acute lymphoblastic leukemia

Frontiers of Medicine 2022, Volume 16, Issue 3,   Pages 442-458 doi: 10.1007/s11684-021-0877-y

Abstract: We found that chidamide, an HDAC inhibitor, exerts an antitumor effect on T-ALL cell lines and primaryIn particular, chidamide inhibits the NOTCH1-MYC signaling axis by down-regulating the level of the intracellularWe also report here the preliminary results of our clinical trial supporting that a treatment by chidamideOur results highlight the effectiveness and safety of chidamide in the treatment of T-ALL patients, including

Keywords： T-cell acute lymphoblastic leukemia     HDAC inhibitor     chidamide     NOTCH1     MYC     ubiquitination    

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Chidamide inhibits the NOTCH1-MYC signaling axis in T-cell acute lymphoblastic leukemia

Journal Article